Research Areas and Sub-Specialties
Physiological Responses to Hypoxia
Research
in this area focuses on an integrated understanding of mouse hypoxic
exercise tolerance. Previous results have shown that two genetic
loci are principally responsible for large differences in endurance
exercise under hypoxic conditions in three strains of mice. These
differences are manifested once the mice have been acclimated to
hypoxia. The ultimate goal is to understand the genetic basis for
acclimation responses that occur at the biochemical, physiological
and whole organism level to promote hypoxic exercise tolerance.
We use a variety of tools in these studies including cDNA microarrays,
nuclear magnetic resonance spectroscopy, light and electron microscopes,
respiratory chambers, as well as a variety of standard biochemical
approaches. This research has relevance to acclimatization to high
altitude, to exercise physiology, and to the manner in which
cells and tissues respond to hypoxia in general, which is which
is an important correlate to many disease states.
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