Quorum sensing is the phenomenon of communication between bacterial cells. Bacteria communicate with each other through signaling molecules. When a “quorum” is reached the signaling molecules induce virulence factors which allow the bacteria to work in concert to harm the host. This project describes the synthesis of novel quorum sensing molecules that can interfere with bacterial communication. These new molecules are acyl homoserine lactones, similar in structure to that of N-3-(4-hydroxphenyl)propanoyl homoserine lactone, which had been identified earlier to be a good signaling molecule. These molecules have been made to determine the structural features of N-3-(4-hydroxphenyl)propanoyl homoserine lactone that are important for its signaling properties. There were four molecules that were synthesized, isolated and purified during the course of this project. In all four molecules an acyl component containing a phenyl ring is connected to the homoserine lactone, and with respect to the placement and composition of the substituent on the phenyl ring.