The Behavioral Effects of Neurotoxic Doses of Methamphetamine and MDMA on Spatial Learning in Rats

Abstract: The effects of neurotoxic doses of methamphetamine and MDMA on spatial learning were assessed using a repeated-acquisition and performance task adapted to the Morris Swim Task. Spatial learning was assessed by measuring the mean escape latency, swim path ratio, and swim speed of all rats in each drug condition for both performance and acquisition. The results indicated that there was no effect of neurotoxic doses of methamphetamine or MDMA on spatial learning. These findings are compared to other studies that measured the neurotoxic effects of methamphetamine and MDMA effects on learning.